Biochem/physiol Actions

Cell permeable: no

Reversible: no

Target IC₅₀: 240 nM against GABA receptors

Product does not compete with ATP.

Primary TargetGABA receptors

General description

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^- channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system. Inhibits ³⁵S-TBPS binding to the Cl^– channel (IC₅₀ = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.Yoon, K.W., et al. 1993. J. Physiol.464, 423.Akaike, N., et al. 1985. Experientia41, 70.

Warning

Toxicity: Highly Toxic (H)